Deregulated Ca cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore,MD21201, USA. Divisionof CardiovascularMedicine,Department ofMedicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA. Department of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA. *These authors contributed equally to this work. †Present address: Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA. ‡Present address: Brigham Young University–J. Reuben Clark Law School, 341 East Campus Drive, Provo, UT 84602, USA. §Present address: FUJIFILM VisualSonics, 3080 Yonge Street, Suite 6300, Toronto, Ontario M4N 3N1, Canada. ¶Corresponding author. Email: [email protected]